Researchers Find New Pathway to Regulate Immune Response

Researchers at The University of Texas at Arlington have found a potential new pathway to regulate immune response and potentially control inflammatory diseases of the central nervous system such as meningitis and sepsis.

“We need to know what turns on inflammatory response to bacterial infection to be able to modulate the process,” said Subhrangsu Mandal, the UTA associate professor of chemistry who led the research.

“If we can do so, we can control inflammatory diseases of the central nervous system that have been hard to treat up to now, such as sepsis and meningitis, as well as cancer and muscular dystrophy, which can also be seen a kind of inflammation,” he added.

Mandal and his team’s research findings were published in Scientific Reports.

The researchers have found that the long non-coding RNA molecule HOTAIR present in white blood cells has the capacity to signal these cells to activate immune response in the presence of bacteria. RNA, or ribonucleic acid, is present in all living cells. Its primary role is to carry instructions from DNA.

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